Spindly (SPDL1) Rabbit Polyclonal Antibody

SKU TA322305

Anti-SPDL1 Rabbit Polyclonal Antibody

Product Data

• Application: IHC, WB
• Recommended Dilution: WB: 500-2000; WB positive control: Hela, 293T, Jurkat cell, Mouse testis tissue, K562, A549 cell lysates; IHC: 50-200; Positive control: Human thyroid cancer; Predicted cell location: Nucleus
• Reactivity: Human, Mouse
• Antibody Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Fusion protein corresponding to C terminal 250 amino acids of human spindle apparatus coiled-coil protein 1
• Buffer: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Shipping: Blue Ice
• Gene Name: spindle apparatus coiled-coil protein 1
• Database Link:
  NP_060255
  Q96EA4
• Background: Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment. Interacts with KNTC1 and ZW10. These interactions appear weak and may be transient or indirect.
• Synonyms: CCDC99

Reference Data