CDC6 Rabbit Polyclonal Antibody

SKU TA321316

Anti-CDC6 Rabbit Polyclonal Antibody

Product Data

• Application: IHC, WB
• Recommended Dilution: WB: 200-1000; WB positive control: K562 cells; IHC: 25-100; Positive control: Human lung cancer; Predicted cell location: Cytoplasm or Nucleus
• Reactivity: Human
• Antibody Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a region derived from 18-32 amino acids of human cell division cycle 6 homolog (S. cerevisiae)
• Buffer: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Shipping: Blue Ice
• Predicted Protein Size: 63 kDa
• Gene Name: cell division cycle 6
• Database Link:
  NP_001245
  Q99741
• Background: The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6; a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cyle G1; but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cyle is regulated through its phosphorylation by Cdks. Transcription of this protein was reported to be regulated in response to mitogenic signals through transcriptional control mechanism involving E2F proteins.
• Synonyms: CDC18L; HsCDC6; HsCDC18

Reference Data

• Protein Pathways: Cell cycle