ABH2 (ALKBH2) Rabbit Polyclonal Antibody

SKU TA321251

Anti-ALKBH2 Rabbit Polyclonal Antibody

Product Data

• Application: WB
• Recommended Dilution: WB: 500-2000; WB positive control: Human fetal liver and seminoma tissue, RAW264.7 cells
• Reactivity: Human, Mouse
• Antibody Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Full length fusion protein
• Buffer: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Shipping: Blue Ice
• Predicted Protein Size: 29 kDa
• Gene Name: alkB homolog 2, alpha-ketoglutarate-dependent dioxygenase
• Database Link:
  NP_001001655
  Q6NS38
• Background: The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA. ALKBH2 and ALKBH3 are E. coli AlkB homologs that catalyze the removal of 1-methyladenine and 3-methylcytosine. Dioxygenase that repairs alkylated DNA and RNA containing 1-methyladenine and 3-methylcytosine by oxidative demethylation. Can also repair alkylated DNA containing 1-ethenoadenine (in vitro). Has strong preference for double-stranded DNA. Has low efficiency with single-stranded substrates. Requires molecular oxygen; alpha-ketoglutarate and iron.
• Synonyms: ABH2

Reference Data

• Protein Families: Druggable Genome