Amylin (IAPP) Rabbit Polyclonal Antibody

SKU TA321122

Anti-IAPP Rabbit Polyclonal Antibody

Product Data

• Application: WB
• Recommended Dilution: WB: 200-1000; WB positive control: Raji cells
• Reactivity: Human, Mouse, Rat
• Antibody Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a region derived from 40-52 amino acids of Human Islet amyloid polypeptide
• Buffer: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Shipping: Blue Ice
• Predicted Protein Size: 10 kDa
• Gene Name: islet amyloid polypeptide
• Database Link:
  NP_000406
  P10997
• Background: Islet; or insulinoma; amyloid polypeptide is commonly found in pancreatic islets of patients suffering diabetes mellitus type II; or harboring an insulinoma. While the association of amylin with the development of type II diabetes has been known for some time; a direct causative role for amylin has been harder to establish. Studies suggest that amylin; like the related beta-amyloid (Abeta) associated with Alzheimer's disease; can induce apoptotic cell-death in particular cultured cells; an effect that may be relevant to the development of type II diabetes.
• Synonyms: DAP; IAP

Reference Data

• Protein Families: Druggable Genome, Secreted Protein
• Protein Pathways: Maturity onset diabetes of the young