Angiotensinogen (AGT) Rabbit Polyclonal Antibody

SKU TA321039

Anti-AGT Rabbit Polyclonal Antibody

Product Data

• Application: IHC, WB
• Recommended Dilution: WB: 500-2000; WB positive control: Human liver cancer tissue; IHC: 25-100; Positive control: Human thyroid cancer; Predicted cell location: Cytoplasm
• Reactivity: Human, Mouse, Rat
• Antibody Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a region derived from 34-43 amino acids of human angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
• Buffer: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Shipping: Blue Ice
• Predicted Protein Size: 53 kDa
• Gene Name: angiotensinogen
• Database Link:
  NP_000020
  P01019
• Background: The protein encoded by this gene; pre-angiotensinogen or angiotensinogen precursor; is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product; angiotensin I; is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension; and can cause renal tubular dysgenesis; a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation; and inflammatory bowel disease.
• Synonyms: ANHU; SERPINA8

Reference Data

• Protein Families: Druggable Genome, Secreted Protein
• Protein Pathways: Renin-angiotensin system