SPO11 Goat Polyclonal Antibody

SKU TA321020

Goat Polyclonal Anti-SPO11 Antibody

Product Data

• Application: WB
• Recommended Dilution: WB: 1-3µg/ml
• Reactivity: Human (Expected from sequence similarity: Mouse)
• Antibody Host: Goat
• Clonality: Polyclonal
• Immunogen: internal region of NP_036576.1; NP_937998.1 (NTYATKRDIYYTDSQ)
• Buffer: Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
• Concentration: lot specific
• Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Shipping: Blue Ice
• Gene Name: SPO11, initiator of meiotic double stranded breaks
• Database Link:
  NP_036576
  Q9Y5K1
• Background: Meiotic recombination and chromosome segregation require the formation of double-strand breaks (DSBs) in paired chromosome homologs. During meiosis in yeast, a meiotic recombination protein is covalently-linked to the 5' end of DSBs and is essential for the formation of DSBs. The protein encoded by this gene is similar in sequence and conserved features to the yeast meiotic recombination protein. The encoded protein belongs to the TOP6A protein family. Several transcript variants encoding different isoforms have been found for this gene, but the full-length nature of only two of them have been described. [provided by RefSeq, Jul 2008]
• Synonyms: CT35; SPATA43; TOPVIA
• Note: This antibody is expected to recognize both reported isoforms (NP_036576.1; NP_937998.1)

Reference Data

• Protein Families: Druggable Genome, Transcription Factors