CCR5 Mouse Monoclonal Antibody [Clone ID: eBioT21/8 (T21/8)]
Mouse Anti-Human CD195 (CCR5) Purified (25 ug)
Product Datasheet for 'TA320230'
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|Clone Name||eBioT21/8 (T21/8)|
|Recommend Dilution||Flow, ELISA, IHC, IP, WB|
|Formulation||Aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer|
|Concentration||0.5-1mg/ml (lot dependent)|
|Gene Name||C-C motif chemokine receptor 5 (gene/pseudogene)|
|Background||The eBioT21/8 monoclonal antibody reacts with the amino terminus of human CCR5 (CD195), an approximately 45 kDa member of the G protein-coupled receptor (GPCR) superfamily that binds chemokines including MIP-1α, MIP-1β and RANTES. Human CCR5 is expressed on resting T cells with a memory/effector phenotype, monocytes, macrophages and immature dendritic cells. CCR5 functions as a receptor to direct the chemotaxis of lymphocytes, and is the primary co-receptor for macrophage-tropic Human Immunodeficiency Virus Type 1 (HIV-1), which binds CCR5 through gp120. Binding of the eBioT21/8 monoclonal antibody displays donor variability and may be affected by sub-optimal staining conditions.|
|Protein Families||GPCR, ES Cell Differentiation/IPS, Transmembrane, Druggable Genome|
|Protein Pathways||Cytokine-cytokine receptor interaction, Chemokine signaling pathway, Endocytosis|