SPINK7 Chicken Polyclonal Antibody

SKU TA320055

Chicken Polyclonal ECRG2 Antibody

Product Data

• Application: IHC, WB
• Recommended Dilution: WB: 1 ug/mL, ICC: 5 ug/mL
• Reactivity: Human, Mouse, Rat
• Antibody Host: Chicken
• Isotype: IgY
• Clonality: Polyclonal
• Immunogen: ECRG2 antibody was raised against a 16 amino acid synthetic peptide near the carboxy terminus of human ECRG2.
• Buffer: ECRG2 Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: ECRG2 Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Shipping: Blue Ice
• Gene Name: serine peptidase inhibitor, Kazal type 7 (putative)
• Database Link:
  AAI09386
  P58062
• Background: ECRG2 Antibody: The esophageal cancer-susceptibility gene 2 (ECRG2), also known as SPINK7, is a novel tumor suppressor gene identified from the human esophagus. It interacts directly with metallothionein 2A and urokinase-type plasminogen activator (uPA), and downregulates the activity of uPA, leading to reduced cancer cell migration, invasion and metastasis. ECRG2 forms a complex with uPA and its receptor uPAR, modifying the dynamic association of uPAR with beta1 integrins and disrupting the Src/MAP kinase pathway that normally stimulates cell migration and invasion. ECRG2 may thus represent a novel therapeutic target for cancer.
• Synonyms: ECG2; ECRG2

Reference Data