Mesothelin (MSLN) Mouse Monoclonal Antibody [Clone ID: MN-1]

SKU TA319550

Mouse monoclonal Mesothelin antibody

Product Data

• Clone Name: MN-1
• Application: IHC, WB
• Recommended Dilution: ELISA: 1:10,000 - 1:50,000, WB: 1:1,000, IHC: 1:100
• Reactivity: Human
• Antibody Host: Mouse
• Clonality: Monoclonal
• Immunogen: This antibody was produced in mice by repeated immunizations with a recombinant protein corresponding to the extracellular domain of human mesothelin.
• Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
• Concentration: lot specific
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Shipping: Blue Ice
• Gene Name: mesothelin
• Database Link:
  NP_001170826
  Q13421
• Synonyms: MPF; SMRP
• Note: Anti Mesothelin Antibody recognizes Mesothelin that is a glycosyl-phosphatidylinositol–anchored glycoprotein present on the cell surface of various human solid tumors. The mesothelin (MSLN) gene encodes a 71-kDa precursor protein that is processed to a 40-kDa glycosylphosphatidylinositol–anchored protein that composes the mature portion and an NH2 terminal 31-kDa fragment called megakaryocyte-potentiating factor that is released from the cell. Mesothelin is a tumor differentiation antigen present at low levels on a restricted set of normal adult tissues, such as mesothelium, but aberrantly over expressed in mesotheliomas, ovarian, and pancreatic cancers. The biological functions of mesothelin remain elusive. A recent study showed that mesothelin binds to MUC16/CA125, and that this interaction mediates cell adhesion, suggesting that there may be an important role for MUC16/CA125 and mesothelin in the metastatic spread of ovarian cancer.

Reference Data

• Protein Families: Druggable Genome, Secreted Protein, Transmembrane