beta TRCP2 (FBXW11) Rabbit Polyclonal Antibody

CAT#: TA319474

Rabbit polyclonal Beta TrCP2 antibody

Product Images

WB using Anti-βTrCP2 antibody shows detection of mouse and human βTrCP2 (arrowhead) in NIH3T3 (lane 1) and 293 (lane 2) whole cell lysates.The primary antibody was used at1:200. Detection occurred using HRP conjugated Goat-anti-Rabbit IgG diluted 1:20,000 in blocking buffer (p/n MB-070) for 1 h at 4 ?.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: ELISA: 1:10,000 – 1:100,000, WB: 1:200 to 1:1,000, IF: User Optimized
• Reactivities: Human, Mouse, Dog, Chicken, Bovine, Monkey
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to a region near the N-terminal of human βTrCP2 protein.
• Formulation: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
• Concentration: lot specific
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: F-box and WD repeat domain containing 11
• Database Link:
  NP_036432
  Entrez Gene 103583 MouseEntrez Gene 479291 DogEntrez Gene 708990 MonkeyEntrez Gene 23291 Human
  UniProt ID Q9UKB1
• Synonyms: BTRC2; BTRCP2; FBW1B; Fbw11; FBXW1B; Hos
• Note: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class and, in addition to an F-box, contains multiple WD40 repeats. This gene contains at least 14 exons, and its alternative splicing generates 3 transcript variants diverging at the presence/absence of two alternate exons.

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Hedgehog signaling pathway, Oocyte meiosis, Ubiquitin mediated proteolysis, Wnt signaling pathway