Ribonuclease H2, subunit A (RNASEH2A) Rabbit Polyclonal Antibody

CAT#: TA306706

Reviews ()
Write a review

Rabbit Polyclonal RNAse H2A Antibody



USD 528.00

2 Weeks*

Size
    • 100 ug

Product images

Frequently bought together (3)
Recombinant protein of human ribonuclease H2, subunit A (RNASEH2A)
    • 100 ug

USD 2,950.00


Transient overexpression lysate of ribonuclease H2, subunit A (RNASEH2A)
    • 100 ug

USD 436.00


beta Actin Mouse Monoclonal Antibody, Clone OTI1, Loading Control
    • 30 ul

USD 200.00

Other products for "RNASEH2A"

Specifications

Product Data
Applications IF, WB
Recommended Dilution WB: 1 ug/mL, ICC: 2 ug/mL, IF: 4 ug/mL
Reactivities Human, Mouse, Rat
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen RNAse H2A antibody was raised against a 17 amino acid peptide near the center of human RNAse H2A.
Formulation PBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name ribonuclease H2 subunit A
Background Ribonucleases (RNAses) H are enzymes that hydrolyze the RNA strands of RNA/DNA hybrids. The major role of these enzymes is to remove the RNA strand from the RNA/DNA hybrids that form during DNA replication and repair. RNAse H2 is made up of three subunits; all three are required for RNAse activity. Recent evidence has demonstrated that mutations in RNAse H2A or any of the other subunits result in Aicardi-Goutieres syndrome (AGS), a neurological disorder with similar symptoms to viral brain infections including high levels of IFN-alpha in the cerebral spinal fluid. Similar conditions are observed with mutations in TREX1, a single-stranded DNA exonuclease, suggesting that RNAse H2 and TREX1 may have similar roles, and that mutations in any of these genes lead to an accumulation of intracellular nucleic acids, triggering an inflammatory response through activation of the innate immune system.
Synonyms AGS4; JUNB; RNASEHI; RNHIA; RNHL
Reference Data
Protein Pathways DNA replication
Customer Reviews 
Loading...
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.