Ribonuclease H2, subunit A(RNASEH2A) Rabbit Polyclonal Antibody

CAT#: TA306706

Rabbit Polyclonal RNAse H2A Antibody

Antibody Service


 Product Datasheet for 'TA306706'

USD 371.00


Availability*
2 Weeks

Size
    • 100 ug

Product images

Specifications

Product Data
Applications WB, IF
Recommend Dilution WB: 1 ug/mL, ICC: 2 ug/mL, IF: 4 ug/mL
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Immunogen RNAse H2A antibody was raised against a 17 amino acid peptide near the center of human RNAse H2A.
Isotype IgG
Formulation PBS containing 0.02% sodium azide.
Reconstitution Method Reconstitute with PBS (pH7.3). To use this carrier-free antibody for conjugation experiment, we strongly recommend you to perform another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific)
Purification Affinity chromatography purified via peptide column
Gene Name ribonuclease H2 subunit A
Background Ribonucleases (RNAses) H are enzymes that hydrolyze the RNA strands of RNA/DNA hybrids. The major role of these enzymes is to remove the RNA strand from the RNA/DNA hybrids that form during DNA replication and repair. RNAse H2 is made up of three subunits; all three are required for RNAse activity. Recent evidence has demonstrated that mutations in RNAse H2A or any of the other subunits result in Aicardi-Goutieres syndrome (AGS), a neurological disorder with similar symptoms to viral brain infections including high levels of IFN-alpha in the cerebral spinal fluid. Similar conditions are observed with mutations in TREX1, a single-stranded DNA exonuclease, suggesting that RNAse H2 and TREX1 may have similar roles, and that mutations in any of these genes lead to an accumulation of intracellular nucleic acids, triggering an inflammatory response through activation of the innate immune system.
Synonyms AGS4|JUNB|RNASEHI|RNHIA|RNHL
Reference Data
Protein Pathways DNA replication
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

Citations