IL18 Goat Polyclonal Antibody

SKU TA305919

Goat Anti-IL18 Antibody

Product Data

• Application: FC, IF, WB
• Recommended Dilution: Western blot: 1-3µg/ml. 1 h at RT.; Approx 23kDa band observed in lysates of cell line HeLa and approx. 21-22kDa band in lysates of cell lines A431 and U2OS (calculated MW of 22.3kDa according to NP_001553.1).; Immunofluorescence: 10µg/ml.; Strong expression of the protein seen in the golgi and cytoplasm of A431and U2OS cells.; Flow Cytometry: Flow cytometric analysis of A431 cells. Recommended concentration: 10ug/ml.
• Reactivity: Human
• Antibody Host: Goat
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Peptide with sequence C-NPPDNIKDTKSDI, from the internal region of the protein sequence according to NP_001553.1.
• Buffer: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
• Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20C. Minimize freezing and thawing.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Shipping: Blue Ice
• Gene Name: interleukin 18
• Database Link:
  NP_001553
  Q14116
• Background: The protein encoded by this gene is a proinflammatory cytokine. This cytokine can induce the IFN-gamma production of T cells. The combination of this cytokine and IL12 has been shown to inhibit IL4 dependent IgE and IgG1 production, and enhance IgG2a production of B cells. IL-18 binding protein (IL18BP) can specifically interact with this cytokine, and thus negatively regulate its biological activity. [provided by RefSeq]
• Synonyms: IGIF; IL-1g; IL-18; IL1F4

Reference Data

• Protein Families: Druggable Genome, Secreted Protein
• Protein Pathways: Cytokine-cytokine receptor interaction, Cytosolic DNA-sensing pathway, NOD-like receptor signaling pathway