AIRE Goat Polyclonal Antibody

SKU TA303113

Goat Polyclonal Antibody against AIRE (Internal Region)

Product Data

• Application: IHC, WB
• Recommended Dilution: ELISA: 1:32,000. WB: 0.5-1.0ug/ml. IHC: 2.5ug/ml.
• Reactivity: Cow), Dog, Human, Pig (Expected from sequence similarity: Rat
• Antibody Host: Goat
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Peptide with sequence C-KDVDLSQPRKGRKP, from the internal region of the protein sequence according to NP_000374.1.
• Buffer: Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
• Concentration: lot specific
• Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Shipping: Blue Ice
• Gene Name: autoimmune regulator
• Database Link:
  NP_000374
  O43918
• Background: This gene encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CBP. At least three splice variant mRNAs products have been described including one which results in a premature stop codon and a transcript predicted to be a candidate for nuclear-mediated decay (NMD). Defects in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED). [provided by RefSeq]
• Synonyms: AIRE1; APECED; APS1; APSI; PGA1
• Note: IHC: In paraffin embedded Human Thymus shows nuclear staining in select thymocytes. This product was confirmed in IHC on fetal Pig Thymus.

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Primary immunodeficiency, Ubiquitin mediated proteolysis