MRE11 Rabbit Polyclonal Antibody

SKU TA301767

Rabbit Polyclonal Antibody against Mre11

Product Data

• Application: ChIP, ELISA, FC, ICC/IF, IHC, Immunoblotting, IP, Simple Western, WB
• Recommended Dilution: Chromatin Immunoprecipitation (ChIP), Knockdown Validated, Proximity Ligation Assay, Immunocytochemistry/ Immunofluorescence: 1:200, Immunohistochemistry-Paraffin: 1:10 - 1:500, Immunohistochemistry: 1:10 - 1:500, Simple Western: 1:250, Western Blot: 1:5000, Immunoprecipitation: 3 uL, Flow Cytometry, Immunoblotting, Immunohistochemistry-Frozen, Knockout Validated, ELISA
• Reactivity: Human, Mouse
• Antibody Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Full length human Mre11 protein
• Buffer: Sodium azide
• Purification: Affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Shipping: Blue Ice
• Gene Name: MRE11 homolog A, double strand break repair nuclease
• Database Link:
  NP_005582
  P49959
• Background: The hMre11-hRad50-NBS1 protein plays a central role in the human cellular DNA-Damage response, with recent studies indicating that these proteins help link DNA-damage detection to DNA-repair and cell cycle-checkpoint functions. This protein complex has been implicated in the activation of cell cycle-regulatory pathways, due to the fact that the NBS1 gene mutates in the chromosomal-instability syndrome, Nijmegen breakdown syndrome (NBS), which is characterized by increased cancer incidence, cell cycle checkpoint defects, and ionizing radiation sensitivity.
• Synonyms: ATLD; HNGS1; MRE11; MRE11B

Reference Data

• Protein Families: Druggable Genome, Stem cell - Pluripotency
• Protein Pathways: Homologous recombination, Non-homologous end-joining