INSIG1 Rabbit Polyclonal Antibody

SKU TA301693

Rabbit Polyclonal Antibody against Insig1

Product Data

• Application: ICC/IF, WB
• Recommended Dilution: Western Blot: 2 ug/ml, Immunocytochemistry/ Immunofluorescence: 1:100-1:1000
• Reactivity: Human
• Antibody Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: A synthetic peptide representing an internal region of the human protein (between residues 1-100) according to Swiss-Prot# O15503.
• Buffer: PBS + 30% glycerol and 0.1% sodium azide
• Concentration: lot specific
• Purification: Immunogen affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Shipping: Blue Ice
• Gene Name: insulin induced gene 1
• Database Link:
  NP_005533
  O15503
• Background: Oxysterols regulate cholesterol homeostasis through liver X receptor (LXR) and sterol regulatory element-binding protein (SREBP) mediated signaling pathway. This gene is an insulin-induced gene. It encodes an endoplasmic reticulum (ER) membrane protein that plays a critical role in regulating cholesterol concentrations in cells. This protein binds to the sterol-sensing domains of SREBP cleavage-activating protein (SCAP) and HMG CoA reductase, and is essential for the sterol-mediated trafficking of the two proteins. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
• Synonyms: CL-6; CL6

Reference Data

• Protein Families: Druggable Genome, Transmembrane