Syvn1 Rabbit Polyclonal Antibody

SKU TA301601

Rabbit Polyclonal Antibody against HRD1

Product Data

• Application: ICC/IF, IHC, IP, WB
• Recommended Dilution: Immunohistochemistry: 1:200 - 1:500, Western Blot: 1:1000 - 1:2000, Immunocytochemistry/ Immunofluorescence: 1:500, Knockout Validated, Immunoprecipitation, Immunohistochemistry-Paraffin: 1:200 - 1:500
• Reactivity: Mouse
• Antibody Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: A synthetic peptide made to an internal portion of the human protein (within residues 300-400). [UniProt Q96PK3]
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Shipping: Blue Ice
• Gene Name: synovial apoptosis inhibitor 1, synoviolin
• Database Link:
  NP_083045
  Q9DBY1
• Background: HRD1 is a ubiquitin ligase whose expression is induced by the unfolded protein response (UPR) following endoplasmic reticulum stress. Expression of HRD1 protects cells from apoptosis by inducing degradation of abnormally processed proteins that accumulate in the endoplasmic reticulum. HRD1 is expressed in many tissues, strongly expressed in brain, pancreas, liver, kidney and skeletal muscle. It has been reported that Synoviolin/Hrd1 (expressed in rheumatoid synovium) is a novel causative factor for arthropathy by triggering synovial cell outgrowth through its anti-apoptotic effects. HRD1 contains one ring-type zinc finger.
• Synonyms: HRD1; KIAA1810; MGC40372

Reference Data