BAP1 Mouse Monoclonal Antibody [Clone ID: 1G8]

SKU TA301480

Mouse Monoclonal Antibody against BAP1 (1G8)

Product Data

• Clone Name: 1G8
• Application: FC, WB
• Recommended Dilution: Western Blot: 2 ug/ml, Flow Cytometry: 1 ug per million cells
• Reactivity: Human
• Antibody Host: Mouse
• Isotype: IgG1, kappa
• Clonality: Monoclonal
• Immunogen: Full-length human BAP1 protein expressed and purified from E.coli. [Uniprot# Q92560]
• Buffer: Tris-glycine, 150mM NaCl and 0.05% sodium azide
• Purification: protein G purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Shipping: Blue Ice
• Gene Name: BRCA1 associated protein 1
• Database Link:
  NP_004647
  Q92560
• Background: Mutations within the BRCA1 gene, localized to chromosome 17q, are believed to account for approximately 45% of families with increased incidence of both early-onset breast cancer and ovarian cancer. The BRCA1 gene is expressed in numerous tissues, including breast and ovary, and encodes a predicted protein of 1863 amino acids. This protein contains a RING domain near the N-terminus and appears to encode a tumor suppressor. BARD1 (BRCA1-associated RING domain protein 1) and BAP1 (BRCA1-associated protein 1) have both been shown to bind to the N-terminus of BRCA1 and are potential mediators of tumor suppression. BARD1 contains an N-terminal RING domain and three tandem ankyrin repeats. The C-terminus of BARD1 contains a region with sequence homology to BRCA1, termed the BRCT domain. BAP1 is a ubiquitin hydrolase and has been shown to enhance BRCA1-mediated cell growth suppression.
• Synonyms: hucep-6; HUCEP-13; UCHL2

Reference Data

• Protein Families: Druggable Genome, Protease