MSH6 Mouse Monoclonal Antibody [Clone ID: 44]

SKU DM429

MSH6 mouse monoclonal antibody, clone 44, Supernatant

Product Data

• Clone Name: 44
• Application: IHC, IP, WB
• Recommended Dilution: Immunoprecipitation.; Western Blot: 1/100-1/500.; Immunohistochemistry on Formalin-Fixed Paraffin Embedded Sections: 1/25-1/50 in an ABC method (30 to 60 minutes at room temperature (requires high temperature antigen unmasking with 10 mM citrate buffer, pH 6.0 prior to immunostaining).; Immunohistochemistry on Frozen Sections.; Recommended Positive Control: Tonsil, colon carcinoma
• Reactivity: Canine, Human, Mouse, Rat
• Antibody Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Synthetic human MSH6 peptide
• Specificity: MSH6 is a heterodimer of MSH2 binds to DNA containing G/T mismatches.; The MSH2-MSH6 complex recognizes a single-based mispair insertion/deletion loop.; Cellular Localization: Nuclear.
• Buffer: State: Supernatant; State: Liquid purified Ig fraction containing Sodium Azide as preservative.
• Purification: Affinity Chromatography.
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.; Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Shipping: Blue Ice
• Gene Name: mutS homolog 6
• Database Link:
  P52701
• Background: An alteration of microsatellite repeats is the result of slippage owing to strand misalignment during DNA replication and is referred to as microsatellite instability (MSI). These defects in DNA repair pathways have been related human carcinogenesis. Studies have shown the mutations of MLH-1, MSH2 and MSH6 genes contribute to the development of sporadic colorectal carcinoma. The repair of mismatch DNA is essential to maintaining the integrity of genetic information over time.
• Synonyms: DNA mismatch repair protein Msh6, GTBP

Reference Data