TIE2 (TEK) Mouse Monoclonal Antibody [Clone ID: Cl.2]

SKU DM3509

TIE2 (TEK) mouse monoclonal antibody, clone Cl.2, Purified

Product Data

• Clone Name: Cl.2
• Application: ELISA, FC, IHC, WB
• Recommended Dilution: ELISA: 1-15 µg/ml. ; Western blot: 1-5 µg/ml. ; FACS and cell sorting: 2-5 µg/ml. ; Immunohistochemistry on Frozen Sections: 1-5 µg/ml.
• Reactivity: Human
• Antibody Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Recombinant Human soluble extracellular domain of TIE-2.
• Specificity: This monoclonal antibody will detect native Human TIE-2/tek in ELISA experiments and on the surface of different Human cell types.
• Buffer: PBS, pH 7.4 without preservatives or stabilizers; State: Purified; State: Lyophilized purified IgG fraction
• Reconstitution Method: Restore in sterile water to a concentration of 0.1-1.0 mg/ml.
• Purification: Affinity Chromatography on Protein G
• Conjugation: Unconjugated
• Storage:

  Prior to reconstitution store at 2-8°C.; Following reconstitution store undiluted at 2-8°C for one month; or (in aliquots) at -20°C for longer.; Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Shipping: Ambient
• Gene Name: TEK receptor tyrosine kinase
• Database Link:
  Q02763
• Background: TIE2 (tyrosine kinase with Ig and EGF homology domains 2) is expressed almost exclusively in endothelial cells in mice, rats and humans. This receptor possesses a unique extracellular domain containing two immunoglobulin like loops separated by three epidermal growth factor like repeats that are connected to three fibronectin type III like repeats. The ligand for the receptor is Angiopoietin 1. Defects in TIE2 are associated with inherited venous malformations; the TIE2 signaling pathway appears to be critical for endothelial cell smooth muscle cell communication in venous morphogenesis.
• Synonyms: TIE2, TIE-2, Angiopoietin-1 receptor, p140 TEK

Reference Data