Granzyme K (GZMK) Mouse Monoclonal Antibody [Clone ID: GM24C3]

SKU DM1209

Granzyme K (GZMK) mouse monoclonal antibody, clone GM24C3, Purified

Product Data

• Clone Name: GM24C3
• Application: ELISA, FC
• Recommended Dilution: Flow Cytometry: 1.2 µg/10⁶ cells.; ELISA: 1/200-1/400.; Cell based ELISA with intakt, transiently transfected cells: 1/200-1/400.
• Reactivity: Human
• Antibody Host: Mouse
• Isotype: IgG2b
• Clonality: Monoclonal
• Immunogen: GM24C3 was generated by genetic immunisation of BALB/c mice with an immunisation vector containing the Granzyme K cDNA
• Specificity: This antibody recognizes Granzyme K (GZMK).
• Buffer: PBS, pH 7.2 without preservatives; State: Purified; State: Liquid purified IgG fraction.
• Concentration: lot specific
• Purification: Affinity Chromatography on Protein G
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.; Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Shipping: Blue Ice
• Gene Name: granzyme K
• Database Link:
  P49863
• Background: Granzyme K (GrK) belongs to a family of trypsin-like serine proteases localised in the cytotoxic granules of activated T cells and NK cells. It encodes a 28 kDa serine protease whose gene is located on chromosome 5q11-12 close to the granzyme A-encoding gene. Like granzyme A, it has a trypsin-like specifity cleaving at the basic residues arginine and lysine. Granzyme K triggers rapid cell death independently of caspase activation with single-stranded DNA nicks and is primarily expressed in thymus, lung, spleen and peripheral blood leukocytes.
• Synonyms: Granzyme-3, NK-tryptase-2, Fragmentin-3, TRYP2, NK-Tryp-2
• Note: Selection: based on recognition of the complete native protein expressed on transfected mammalian cells.

Reference Data