Thymine DNA glycosylase (TDG) Mouse Monoclonal Antibody [Clone ID: OTI3C11]

CAT#: CF808610

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Carrier-free (BSA/glycerol-free) TDG mouse monoclonal antibody, clone OTI3C11 (formerly 3C11)

Formulation: Standard Carrier-Free



  View other "OTI3C11" antibodies (4)

USD 600.00

In Stock*

Size
    • 100 ug

Frequently bought together (2)
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Specifications

Product Data
Clone Name OTI3C11
Applications IHC, WB
Recommended Dilution WB 1:2000, IHC 1:150
Reactivities Human, Mouse, Rat
Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen Human recombinant protein fragment corresponding to amino acids 160-253 of human TDG(NP_003202) produced in E.coli.
Formulation Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Reconstitution Method For reconstitution, we recommend adding 100uL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiment, we strongly recommend performing another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific)
Purification Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Predicted Protein Size 45.9 kDa
Gene Name Homo sapiens thymine DNA glycosylase (TDG), transcript variant 1, mRNA.
Background The protein encoded by this gene belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase (TDG) removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. This gene may have a pseudogene in the p arm of chromosome 12. [provided by RefSeq, Jul 2008]
Synonyms hTDG
Reference Data
Protein Families Druggable Genome
Protein Pathways Base excision repair

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