TIM 3 (HAVCR2) Mouse Monoclonal Antibody [Clone ID: OTI2E2]

CAT#: CF807034

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Carrier-free (BSA/glycerol-free) HAVCR2 mouse monoclonal antibody, clone OTI2E2 (formerly 2E2)



  View other "OTI2E2" antibodies (4)

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USD 495.00


Availability*
In Stock

Size
    • 100 ug


Specifications

Product Data
Clone Name OTI2E2
Applications IHC, WB
Recommended Dilution IHC 1:150
Reactivity Human
Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen Human recombinant protein fragment corresponding to amino acids 22-202 of human HAVCR2(NP_116171) produced in E.coli.
Formulation Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Reconstitution Method For reconstitution, we recommend adding 100uL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiment, we strongly recommend performing another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific)
Purification Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Predicted Protein Size 33.2 kDa
Gene Name Homo sapiens hepatitis A virus cellular receptor 2 (HAVCR2), mRNA.
Background The protein encoded by this gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance. [provided by RefSeq, Sep 2011]
Synonyms CD366; HAVcr-2; KIM-3; Tim-3; TIM3; TIMD-3; TIMD3
Reference Data
Protein Families Druggable Genome, Transmembrane

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