STAT5A Mouse Monoclonal Antibody [Clone ID: OTI4H1]
CAT#: CF500006
Carrier-free (BSA/glycerol-free) Stat5a mouse monoclonal antibody, clone OTI4H1 (formerly 4H1)
Formulation: Standard
Specifications
Product Data | |
Clone Name | OTI4H1 |
Applications | IHC, WB |
Recommended Dilution | WB 1:200~500, IHC 1:50 |
Reactivities | Human, Rat, Mouse |
Host | Mouse |
Isotype | IgG1 |
Clonality | Monoclonal |
Immunogen | Human recombinant protein fragment corresponding to amino acids 2-104 of human Stat5a (NP_003143) produced in E.coli. |
Formulation | Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose) |
Reconstitution Method | For reconstitution, we recommend adding 100uL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiment, we strongly recommend performing another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific) |
Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
Conjugation | Unconjugated |
Storage | Store at -20°C as received. |
Stability | Stable for 12 months from date of receipt. |
Predicted Protein Size | 90.5 kDa |
Gene Name | Homo sapiens signal transducer and activator of transcription 5A (STAT5A), transcript variant 2, mRNA. |
Database Link | |
Background | Stat5a is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. |
Synonyms | MGF; STAT5 |
Reference Data | |
Protein Families | Druggable Genome, ES Cell Differentiation/IPS, Stem cell relevant signaling - DSL/Notch pathway, Stem cell relevant signaling - JAK/STAT signaling pathway, Transcription Factors |
Protein Pathways | Acute myeloid leukemia, Chronic myeloid leukemia, ErbB signaling pathway, Jak-STAT signaling pathway, Pathways in cancer |
Documents
Product Manuals |
FAQs |
SDS |
Resources
Antibody Resources |
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
TA500006 | Stat5a mouse monoclonal antibody, clone OTI4H1 (formerly 4H1) |
USD 447.00 |
|
TA500006AM | Stat5a mouse monoclonal antibody, clone OTI4H1 (formerly 4H1), Biotinylated |
USD 509.00 |
|
TA500006BM | Stat5a mouse monoclonal antibody, clone OTI4H1 (formerly 4H1), HRP conjugated |
USD 509.00 |
|
TA500006S | Stat5a mouse monoclonal antibody, clone OTI4H1 (formerly 4H1) |
USD 200.00 |
|
TA600173 | STAT5A mouse monoclonal capture antibody, validated for ELISA and Luminex assays |
USD 458.00 |
|
TA700170 | STAT5A biotinylated mouse monoclonal detection antibody, validated for ELISA and Luminex assays |
USD 494.00 |
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