Cytokeratin 8 (KRT8) (+ KRT18) Guinea Pig Polyclonal Antibody
Cytokeratin 8 (KRT8) (+ KRT18) guinea pig polyclonal antibody, Serum
|Applications||ELISA, IHC, WB|
Immunoblotting: 1/2000 for Western blotting.
Immunohistochemistry on Frozen Tissue: 1/100.
Immunohistochemistry on Paraffin-Embedded Tissue: 1/50 (microwave treatment recommended).
Incubation Time: 1 h at RT, extended with Paraffin.
|Reactivities||Bovine, Chicken, Hamster, Human, Mouse, Rat, Xenopus|
|Immunogen||Keratin K8/K18 filaments, reconstituted from purified Bovine keratins K8 and K18|
|Specificity||Reactive Polypeptide: Mr 52 500 and 45 500 Keratins K8 and K18 of simple type epithelium.
Tumors Specifically Detected: All adenocarcinoma tested, undifferentiated carcinoma, hepatocellular carcinoma, cervix carcinoma.
State: Liquid stabilized antiserum
Preservative: 0.09% Sodium Azide
|Storage||Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
|Stability||Shelf life: one year from despatch.|
|Gene Name||Homo sapiens keratin 8 (KRT8), transcript variant 2|
|Background||Keratin 8 belongs to the type B (basic) subfamily of high molecular weight keratins and exists in combination with keratin 18. Keratin 8 is primarily found in the non-squamous epithelia and is present in majority of adenocarcinomas and ductal carcinomas. It is absent in squamous cell carcinomas. Hepatocellular carcinomas are defined by the use of antibodies that recognize only cytokeratin polypeptides 8 and 18.|
|Synonyms||KRT8, CYK8, Cytokeratin-8, CK8, Keratin-8, K8, Cytokeratin endo A|
|Protein Families||Druggable Genome|
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