Lamin A/C Mouse Monoclonal Antibody [Clone ID: 131C3]

SKU BM6000P

Lamin A/C mouse monoclonal antibody, clone 131C3, Purified

Product Data

• Clone Name: 131C3
• Application: FC, IF, IHC, WB
• Recommended Dilution: Immunoblotting: 1/100-1/1000.; Flow Cytometry: 1/100-1/200.; Immunocytochemistry.; Immunohistochemistry on Frozen Sections: 1/100-1/200 with avidin-biotinylated horseradish peroxidase complex (ABC) as detection reagent.
• Reactivity: Bovine, Canine, Hamster, Human, Mouse, Rat, Sheep
• Antibody Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Purified Rat liver Lamins.
• Specificity: 131C3 reacts with an epitope located between residues 319-566 in Lamin A and C.; Immunoblotting of 131C3 recognizes Nuclear Lamins A and C in Human Fibroblasts.
• Buffer: PBS; State: Purified; State: Liquid purified IgG fraction; Preservative: 0.09% Sodium Azide
• Concentration: lot specific
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.; Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Shipping: Blue Ice
• Gene Name: lamin A/C
• Database Link:
  P02545
• Background: Nuclear lamins form a network of intermediate-type filaments at the nucleoplasmic site of the nuclear membrane. Two main subtypes of nuclear lamins can be distinguished, i.e. A-type lamins and B-type lamins. The A-type lamins comprise a set of three proteins arising from the same gene by alternative splicing, i.e. lamin A, lamin C and lamin Adel 10, while the B-type lamins include two proteins arising from two distinct genes, i.e. lamin B1 and lamin B2. Recent evidence has revealed that mutations in A-type lamins give rise to a range of rare but dominant genetic disorders, including Emery-Dreifuss muscular dystrophy, dilated cardiomyopathy with conduction-system disease and Dunnigan-type familial partial lipodystrophy. In addition, the expression of A-type lamins coincides with cell differentiation and as A-type lamins specifically interact with chromatin, a role in the regulation of differential gene expression has been suggested for A-type lamins.
• Synonyms: LMNA, LMN1, 70 kDa Lamin, NY-REN-32, NYREN32, Lamin-A/C, Lamin A, Lamin A + C, Nuclear Envelope Marker

Reference Data