ICAM1 Mouse Monoclonal Antibody [Clone ID: MEM-111]
Product Data | |
Clone Name | MEM-111 |
---|---|
Application | ELISA, FC, IHC, WB |
Recommended Dilution | Flow cytometry: Recommended dilution: 0.5-4 μg/ml. Immunohistochemistry (paraffin sections): Recommended dilution: 10 μg/ml; positive tissue: thymus, RE cells. Western blotting: Positive control: RAJI cell line K562 leukemia cell line, JY cell line, aa ctivated T-lymphocytes, non-reducing conditions. |
Reactivity | Bovine, Human, Rat |
Antibody Host | Mouse |
Isotype | IgG2a |
Clonality | Monoclonal |
Immunogen | Raji Human Burkitt's lymphoma cell line. |
Specificity | Clone MEM-111 reacts with CD54. |
Buffer | PBS, pH~7.4 State: Purified State: Liquid purified Ig fraction (95% pure by SDS-PAGE) Preservative: 15mM Sodium Azide |
Concentration | lot specific |
Purification | Affinity Chromatography on Protein A |
Conjugation | Unconjugated |
Storage | Store undiluted at 2-8°C. DO NOT FREEZE! |
Stability | Shelf life: one year from despatch. |
Shipping | Blue Ice |
Gene Name | intercellular adhesion molecule 1 |
Database Link | |
Background | ICAM-1 (MW 90 kD) is a member of the C2 subset of immunoglobulin superfamily. It is a transmembrane molecule with 7 potential N-glycosylated sites, expressed on resting monocytes and endothelial cells and can be upregulated on many other cells, e.g. with lymphokines, on B- and T-lymphocytes, thymocytes, dendritic cells and also on keratinocytes, chondrocytes, as well as epithelial cells. CD54 mediates cell adhesion by binding to integrins CD11a/CD18 (LFA-1) and to CD11b/CD18 (Mac-1). The interaction of CD54 with LFA-1 enhances antigen-specific T-cell activation. |
Synonyms | ICAM-1 |
Reference Data |
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