MAP3K8 pSer400 Rabbit Polyclonal Antibody

SKU AP55762PU-S

MAP3K8 pSer400 rabbit polyclonal antibody, Aff - Purified

Product Data

• Application: IHC
• Recommended Dilution: Immunohistochemistry on paraffin sections: 1:50~1:100 .
• Reactivity: Human, Mouse, Rat
• Antibody Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Peptide sequence around phosphorylation site of Serine 400(C-Q-S(p)-L-D) derived from HumanMAP3K8 (KLH-conjugated)
• Specificity: The antibody detects endogenous levels of MAP3K8 only when phosphorylated at serine 400.
• Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol; State: Aff - Purified; State: Liquid Ig fraction
• Concentration: lot specific
• Purification: Affinity chromatography using epitope-specific peptide
• Conjugation: Unconjugated
• Storage: Upon receipt, store undiluted (in aliquots) at -20°C.; Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Shipping: Blue Ice
• Predicted Protein Size: 52 kDa
• Gene Name: mitogen-activated protein kinase kinase kinase 8
• Database Link:
  P41279
• Background: This gene was identified by its oncogenic transforming activity in cells. The encoded protein is a member of the serine/threonine protein kinase family. This kinase can activate both the MAP kinase and JNK kinase pathways. This kinase was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This kinase was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. Studies of a similar gene in rat suggested the direct involvement of this kinase in the proteolysis of NF-kappaB1,p105 (NFKB1).
• Synonyms: MAPK, Tumor progression locus 2, COT, ESTF

Reference Data