SCN1B (N-term) Rabbit Polyclonal Antibody

CAT#: AP53815PU-N

SCN1B (N-term) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of SCN1B Antibody (N-Term) in Mouse Neuro-2a cell line lysates (35ug/lane). This demonstrates the SCN1B antibody detected the SCN1B protein (arrow).

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  Immunohistochemistry analysis in Formalin Fixed, Paraffin Embedded Human brain tissue stained with SCN1B Antibody (N-term) followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the SCN1B Antibody (N-Term) for immunohistochemistry. Clinical relevance has not been evaluated.

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  Flow Cytometric analysis of Hela cells using SCN1B Antibody (N-Term) (Right histogram) compared to a negative control cell (Left histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.

Specifications

Product Data

• Applications: FC, IHC, WB
• Recommended Dilution: ELISA: 1/1,000.
  Western blotting: 1/100-1/500.
  Flow Cytometry: 1/10-1/50.
  Immunohistochemistry: 1/50-1/100.
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide between 70-98 amino acids from the N-terminal region of Human SCN1B
• Specificity: Recognizes SCN1B (N-Term).
• Formulation: PBS with 0.09% (W/V) Sodium Azide as preservative
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Protein A column followed by peptide Affinity purification
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: sodium voltage-gated channel beta subunit 1
• Database Link:
  Entrez Gene 20266 MouseEntrez Gene 6324 Human
  UniProt ID Q07699
• Background: Voltage-gated sodium channels are heteromeric proteins that function in the generation and propagation of action potentials in muscle and neuronal cells. They are composed of one alpha and two beta subunits, where the alpha subunit provides channel activity and the beta-1 subunit modulates the kinetics of channel inactivation. SCN1B encodes a sodium channel beta-1 subunit. Mutations in this gene result in generalized epilepsy with febrile seizures plus, Brugada syndrome 5, and defects in cardiac conduction. Multiple transcript variants encoding different isoforms have been found for this gene.
• Synonyms: GEFSP1
• Note: Molecular Weight: 24707 Da

Reference Data

• Protein Families: Druggable Genome, Ion Channels: Sodium, Transmembrane