MOBK1B (MOB1A) (N-term) Rabbit Polyclonal Antibody

SKU AP52718PU-N

MOBK1B (MOB1A) (N-term) rabbit polyclonal antibody, Purified

Product Data

• Application: FC, WB
• Recommended Dilution: ELISA: 1/1000. ; Western Blot: 1/100-1/500. ; Flow Cytometry: 1/10-1/50.
• Reactivity: Human
• Antibody Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide between 4-33 amino acids from the N-terminal region of Human MOBKL1B
• Specificity:
  This antibody recognizes Human MOBKL1B (N-term).
• Buffer: PBS containing 0.09% (W/V) Sodium Azide as preservative; State: Purified; State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS
• Conjugation: Unconjugated
• Storage:

  Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.; Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Shipping: Blue Ice
• Gene Name: MOB kinase activator 1A
• Database Link:
  Q9H8S9
• Background: Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38 and STK38L.
• Synonyms: Mob1 homolog 1B, Mob1 alpha, Protein Mob4B, C2orf6, MOB4B, MOBK1B
• Note: Molecular Weight: 25080 Da

Reference Data

• Protein Families: Druggable Genome