Melanophilin (MLPH) (C-term) Rabbit Polyclonal Antibody

SKU AP52706PU-N

Melanophilin (MLPH) (C-term) rabbit polyclonal antibody, Aff - Purified

Product Data

• Application: IHC, WB
• Recommended Dilution:

  Immunohistochemistry on Paraffin sections: 1/10-1/50.; Western blot: 1/100-1/500.; Enzyme immunoassay: 1/1000.

• Reactivity: Human
• Antibody Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: Synthetic peptide - KLH conjugated - corresponding to the C-terminal region (between 540-569aa) of human Melanophilin.
• Specificity: This antibody recognizes Melanophilin / MLPH at C-term.
• Buffer: PBS with 0.09% (W/V) Sodium azide; State: Aff - Purified; State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Purified through a Protein A column followed by peptide affinity purification
• Conjugation: Unconjugated
• Storage:

  Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.; Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Shipping: Blue Ice
• Gene Name: melanophilin
• Database Link:
  Q9BV36
• Background: The MLPH gene encodes a member of the exophilin subfamily of Rab effector proteins, Melanophilin. The protein forms a ternary complex with the small Ras-related GTPase Rab27A in its GTP-bound form and the motor protein myosin Va. A similar protein complex in mouse functions to tether pigment-producing organelles called melanosomes to the actin cytoskeleton in melanocytes, and is required for visible pigmentation in the hair and skin. A mutation in this gene results in Griscelli syndrome type 3, which is characterized by a silver-gray hair color and abnormal pigment distribution in the hair shaft. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.
• Synonyms: Mlph, Ln, Slac2a, Exophilin-3, Leaden protein, Synaptotagmin-like protein 2a
• Note: Molecular Weight: 65949 Da

Reference Data