CPN1 (Center) Rabbit Polyclonal Antibody

CAT#: AP51053PU-N

CPN1 (Center) rabbit polyclonal antibody, Purified

Product Images

Western blot analysis of CPN1 (arrow) using CPN1 Antibody (Center). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the CPN1 gene.

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  Formalin fixed and paraffin embedded human liver tissue stained with CPN1 Antibody (Center) followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of CPN1 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution:

  ELISA: 1/1000.
  Western Blot: 1/50-1/100.
  Immunohistochemistry on Paraffin Sections: 1/10-1/50.

• Reactivities: Human
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide between 209-240 amino acids from the Central region of Human CPN1.
• Specificity: This antibody recognizes Human CPN1 (Center).
• Formulation: PBS
  State: Purified
  State: Liquid purified Ig fraction
  Preservative: 0.09% Sodium Azide
• Concentration: lot specific
• Purification: Affinity Chromatography on Protein A
• Conjugation: Unconjugated
• Storage:

  Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Gene Name: carboxypeptidase N subunit 1
• Database Link:
  Entrez Gene 1369 Human
  UniProt ID P15169
• Background:
  
  

  Carboxypeptidase N is a plasma metallo-protease that cleaves basic amino acids from the C terminal of peptides and proteins. The enzyme is important in the regulation of peptides like kinins and anaphylatoxins, and has also been known as kininase-1 and anaphylatoxin inactivator. This enzyme is a tetramer comprised of two identical regulatory subunits and two identical catalytic subunits; this gene encodes the catalytic subunit. Mutations in this gene can be associated with angioedema or chronic urticaria resulting from carboxypeptidase N deficiency. [provided by RefSeq].

  
  
• Synonyms: CPN, CPN1, ACBP, Kininase-1, Serum carboxypeptidase N, Anaphylatoxin inactivator, Plasma carboxypeptidase B, Lysine carboxypeptidase, Arginine carboxypeptidase, SCPN
• Note: Molecular Weight: 52286 Da

Reference Data

• Protein Families: Druggable Genome, Protease, Secreted Protein