C6orf150 (MB21D1) (Center) Rabbit Polyclonal Antibody

SKU AP50874PU-N

C6orf150 (MB21D1) (Center) rabbit polyclonal antibody, Aff - Purified

Product Data

• Application: FC, WB
• Recommended Dilution: ELISA: 1/1000.; Western Blot: 1/1000. ; Flow Cytometry: 1/10-1/50.
• Reactivity: Human
• Antibody Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide between 266-295 amino acids from the Central region of Human CF150
• Specificity: This antibody recognizes Human C6orf150 (CF150). Other species not tested.
• Buffer: PBS; State: Aff - Purified; State: Liquid purified Ig fraction; Preservative: 0.09% (W/V) Sodium Azide
• Concentration: lot specific
• Purification: Protein A Chromatography followed by peptide affinity purification
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.; Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Shipping: Blue Ice
• Predicted Protein Size: 58814 Da
• Gene Name: Mab-21 domain containing 1
• Database Link:
  Q8N884
• Background: Function: Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP. Catalysis involves both the formation of a 2',5' phosphodiester linkage at the GpA step and the formation of a 3',5' phosphodiester linkage at the ApG step, producing c[G(2',5')pA(3',5')p]. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of double- stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production. ; Cellular Location: Cytoplasm, cytosol. ; Tissue Location: Expressed in the monocytic cell line THP1.
• Synonyms: C6orf150; cGAS; h-cGAS

Reference Data