Telomerase reverse transcriptase (TERT) (627-656) Rabbit Polyclonal Antibody

SKU AP33476PU-N

Telomerase reverse transcriptase (TERT) (627-656) rabbit polyclonal antibody, Purified

Product Data

• Application: FC, IF, IHC, WB
• Recommended Dilution: Flow Cytometry: 1/10 - 1/50.; Immunofluorescence: 1/10 - 1/50.; Immunohistochemistry on Paraffin Sections: 1/100.; Western Blot: 1/1000.
• Reactivity: Human
• Antibody Host: Rabbit
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide selected from the Center region of Human TERT. ; Epitope: 627-656
• Specificity: This antibody detects Human TERT at center.; Other species not tested.
• Buffer: PBS; State: Purified; State: Liquid Ig fraction; Preservative: 0.09% (W/V) Sodium Azide
• Purification: Ammonium Sulfate Precipitation
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.; Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Shipping: Blue Ice
• Predicted Protein Size: 126997 Da
• Gene Name: telomerase reverse transcriptase
• Database Link:
  O14746
• Background: Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks.
• Synonyms: Telomerase reverse transcriptase, HEST2, EST2, TCS1, TRT

Reference Data