TAPA1 (CD81) Rat Monoclonal Antibody [Clone ID: QV-6A8-S3]

SKU AP32979PU-N

TAPA1 (CD81) rat monoclonal antibody, clone QV-6A8-S3, Purified

Product Data

• Clone Name: QV-6A8-S3
• Application: ELISA, FC, WB
• Recommended Dilution: Flow Cytometry: 1.2 µg/10⁶ cells.; ELISA: 1/200-1/400.; Cell based ELISA with intakt, transiently transfected cells: 1/200-1/400.
• Reactivity: Human
• Antibody Host: Rat
• Isotype: IgG2b
• Clonality: Monoclonal
• Immunogen: cDNA encoding Human CD81
• Specificity: Recognizes Human CD81. ; Other species not tested.; Selection: Based on recognition of the complete native protein expressed on transfected mammalian cells.
• Buffer: PBS, pH 7.2; State: Purified; State: Liquid purified IgG fraction
• Concentration: lot specific
• Purification: Affinity Chromatography on Protein G
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.; Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Shipping: Blue Ice
• Gene Name: CD81 molecule
• Database Link:
  P60033
• Background: CD81 (TAPA-1) belongs to the transmembrane 4 superfamily (tetraspanin family). CD81 is a widely expressed cell-surface protein that is characterized by the presence of four transmembranic domains, short N and C termini, a small extracellular loop (SEL) and a large extra-cellular loop (LEL) (1). It is expressed on cells of hematopoietic, neuroectodermal and mesenchymal origin and plays a role in the regulation of cell development, cell-growth and signal transduction. CD81 plays a critical role in Hepatitis C Infection and is involved in HCV entry due to its ability to interact with virus' E1/E2 glycoproteins (2,3). CD81 is an essential HCV host factor as silencing of CD81 expression by CD81-specific monoclonal antibodies in hepatoma cells inhibits HCV entry (4).
• Synonyms: S5.7; TAPA-1; TAPA1; Tetraspanin-28; Tspan-28; TSPAN28

Reference Data