ACTN3 (N-term) Rabbit Polyclonal Antibody
| Product Data | |
| Application | ELISA, IHC, WB |
|---|---|
| Recommended Dilution | ELISA: 1/20000. Immunohistochemistry on Paraffin Sections: 1/100. Western Blot: 1/500 - 1/1000. |
| Reactivity | Human, Mouse, Rat |
| Antibody Host | Rabbit |
| Isotype | IgG |
| Clonality | Polyclonal |
| Immunogen | ACTN3 antibody was raised against synthetic peptide - KLH conjugated |
| Specificity | This antibody reacts to the N-term of Alpha-actinin 3, Skeletal Muscle Isoform (ACTN3). |
| Buffer | PBS (without Mg2+, Ca2+), pH 7.4 containing 150 mM sodium chloride, 0.02% sodium azide as preservative and 50% glycerol as stabilizer State: Liquid purfied Ig fraction |
| Concentration | lot specific |
| Purification | Immunoaffinity Chromatography |
| Conjugation | Unconjugated |
| Storage | Store the antibody at -20°C. Avoid repeated freezing and thawing. |
| Stability | Shelf life: one year from despatch. |
| Shipping | Blue Ice |
| Gene Name | actinin alpha 3 (gene/pseudogene) |
| Database Link | |
| Background | Alpha-actinin is an actin-binding protein with multiple roles in different cell types. ACTN3 expression is limited to skeletal muscle. It is localized to the Z-disc and analogous dense bodies, where it helps to anchor the myofibrillar actin filaments. |
| Synonyms | Alpha actinin skeletal muscle isoform 3 |
| Reference Data | |
| Protein Pathways | Adherens junction, Arrhythmogenic right ventricular cardiomyopathy (ARVC), Focal adhesion, Leukocyte transendothelial migration, Regulation of actin cytoskeleton, Systemic lupus erythematosus, Tight junction |
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