Col17a1 Rabbit Polyclonal Antibody

SKU AP23435PU-S

Col17a1 rabbit polyclonal antibody, Purified

Product Data

• Application: IF, IHC
• Recommended Dilution: Immunofluorescence.; Immunohistochemistry on Cryosections.
• Reactivity: Mouse
• Antibody Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Mouse COL17A
• Specificity: Recognizes Mouse Collagen type XVII. Other species not tested.
• Buffer: PBS pH 7.4; State: Purified; State: Lyophilized purified IgG fraction from Serum
• Reconstitution Method: Restore in aqua bidest to initial volume
• Purification: Protein G Chromatography
• Conjugation: Unconjugated
• Storage: Store lyophilized at 2-8°C for 6 months or at -20°C long term.; After reconstitution store the antibody undiluted at 2-8°C for one month ; or (in aliquots) at -20°C long term.; Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Shipping: Ambient
• Gene Name: collagen, type XVII, alpha 1
• Database Link:
  Q07563
• Background: Unlike most collagens, collagen XVII is a transmembrane protein. Collagen XVII is a structural component of hemidesmosomes, multiprotein complexes at the dermal epidermal basement membrane zone that mediate adhesion of keratinocytes to the underlying membrane. Mutations in the gene coding for collagen XVII are associated with both generalized atrophic benign and junctional epidermolysis bullosa. Two homotrimeric forms of type XVII collagen exist. The full length form is the transmembrane protein. A soluble form, referred to as either ectodomain or LAD 1, is generated by proteolytic processing of the full length form. Two transcript variants, one resulting from alternative splicing in the 3' UTR, have been identified for this gene.
• Synonyms: COL17A1, BP180, BPAG2, Bullous pemphigoid antigen 2, LAD-1, LABD97

Reference Data