c Fos (FOS) (N-term) Rabbit Polyclonal Antibody

SKU AP23413PU-N

c Fos (FOS) (N-term) rabbit polyclonal antibody, Aff - Purified

Product Data

• Application: WB
• Recommended Dilution: Western blot: 1 μg/ml.
• Reactivity: Human, Mouse, Rat
• Antibody Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: A synthetic peptide corresponding to a sequence at the middle region of human C-FOS
• Specificity: This antibody detects c-fos (N-term).
• Buffer: 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3; State: Aff - Purified; State: Lyophilized Ig fraction
• Reconstitution Method: 0.2ml of distilled water will yield a concentration of 500μg/ml.
• Purification: Immunogen affinity purified
• Conjugation: Unconjugated
• Storage: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Shipping: Ambient
• Gene Name: Fos proto-oncogene, AP-1 transcription factor subunit
• Database Link:
  P01100
• Background: The human oncogene c-fos is cellular homolog of the transforming gene of Finkel-Biskis-Jinkins (FBJ)murine osteosarcoma virus which was mapped to a single human chromosome.1 c-Fos is encoded by the FOS gene. FOS was the first transcription factor identified that has a critical function in regulating the development of cells destined to form and maintain the skeleton. FOS is also a major component of the activator protein-1 (AP-1) transcription factor complex, which includes members of the JUN family.c-fos is a major nuclear target for signal transduction pathways involved in the regulation of cell growth,differentiation, and transformation.2 Using transgenic and knockout mice, Grigoriadis et al. (1995) established a unique role for the proto-oncogene and nuclear transcription factor, Fos, in regulating thedifferentiation and activity of specific bone cell populations, both during normal development and in bone disease.
• Synonyms: FOS, G0S7

Reference Data

• Protein Families: Druggable Genome, Transcription Factors
• Protein Pathways: B cell receptor signaling pathway, Colorectal cancer, MAPK signaling pathway, Pathways in cancer, T cell receptor signaling pathway, Toll-like receptor signaling pathway