MET (C-term) Rabbit Polyclonal Antibody

SKU AP22713PU-N

MET (C-term) rabbit polyclonal antibody, Purified

Product Data

• Application: IHC
• Recommended Dilution: Immunohistochemistry on Paraffin Sections: 15 µg/ml.
• Reactivity: Human
• Antibody Host: Rabbit
• Clonality: Polyclonal
• Immunogen: MET antibody was raised against a synthetic peptide from C-terminus of human c-Met protein
• Specificity: This antibody reacts to Hepatocyte Growth Factor Receptor (MET).
• Buffer: 10mM PBS/1% BSA buffer pH 7.4 with 0.09% sodium azide.; State: Purified; State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Immunoaffinity Chromatography
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted at 2-8°C.; DO NOT FREEZE!
• Stability: Shelf life: one year from despatch.
• Shipping: Blue Ice
• Gene Name: MET proto-oncogene, receptor tyrosine kinase
• Database Link:
  P08581
• Background: Met, an HGF Receptor/Met type protein kinase, is a cell-surface proto-oncogene that mediates the biological activities of hepatocyte growth factor. The protein is a disulfide-linked heterodimer comprised of two subunits: a 50 kD extracellular alpha subunit and a membrane-spanning 145 kD beta subunit that binds ligand. Met is an important regulator of cell proliferation and differentiation, organ regeneration, embryogenesis, and tumorogenesis. Constitutive activation mutations of the met gene lead to many cancers, particularly renal papillary carcinoma.
• Synonyms: Hepatocyte growth factor receptor, MET, Scatter factor receptor, HGF/SF receptor, c-Met

Reference Data

• Protein Families: Druggable Genome, Protein Kinase, Transmembrane
• Protein Pathways: Adherens junction, Axon guidance, Colorectal cancer, Cytokine-cytokine receptor interaction, Endocytosis, Epithelial cell signaling in Helicobacter pylori infection, Focal adhesion, Melanoma, Pathways in cancer, Renal cell carcinoma