VAV3 (567-578) Goat Polyclonal Antibody

SKU AP22535PU-N

VAV3 (567-578) goat polyclonal antibody, Aff - Purified

Product Data

• Application: ELISA, IHC, WB
• Recommended Dilution: ELISA: 1/128000.; Immunohistochemistry on Paraffin Sections: 5 µg/ml.; Western Blot: 0.3 - 1 µg/ml.
• Reactivity: Human, Monkey
• Antibody Host: Goat
• Clonality: Polyclonal
• Immunogen: Synthetic peptide from an internal region of human VAV3
• Specificity: This antibody detects VAV3 (Internal).
• Buffer: Tris saline buffer, pH 7.3, 0.5% BSA, 0.02% sodium azide; State: Aff - Purified; State: Liquid Ig fraction
• Concentration: lot specific
• Purification: Immunoaffinity chromatography
• Conjugation: Unconjugated
• Storage: Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Shipping: Blue Ice
• Gene Name: vav guanine nucleotide exchange factor 3
• Database Link:
  Q9UKW4
• Background: Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the nucleotide-free states of those GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity). May be important for integrin-mediated signaling, at least in some cell types.
• Synonyms: VAV-3

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: B cell receptor signaling pathway, Chemokine signaling pathway, Fc epsilon RI signaling pathway, Fc gamma R-mediated phagocytosis, Focal adhesion, Leukocyte transendothelial migration, Natural killer cell mediated cytotoxicity, Regulation of actin cytoskeleton, T cell receptor signaling pathway