ALDH5A1 (485-496) Goat Polyclonal Antibody

SKU AP22390PU-N

ALDH5A1 (485-496) goat polyclonal antibody, Aff - Purified

Product Data

• Application: ELISA, IHC, WB
• Recommended Dilution: Peptide ELISA: 1/32000 (Detection Limit). ; Western blot: 0.3-1 µg/ml. This antibody detects a band of Approx 55kDa in Human Liver lysates and 50kDa band in Mouse and Rat Liver lysates.; Immunohistochemistry on Paraffin Sections: 5-10 µg/ml. In paraffin embedded Human Liver shows heavy textured cystoplasm staining in hepatocytes, consistent with mitochondia.
• Reactivity: Bovine, Canine, Human, Mouse, Rat
• Antibody Host: Goat
• Clonality: Polyclonal
• Immunogen: Peptide with sequence from the internal region of Human ALDH5A1.
• Specificity: This antibody is expected to recognize both reported isoforms (NP_733936.1; NP_001071.1).
• Buffer: Tris saline, pH~7.3; State: Aff - Purified; State: Liquid purified Ig fraction; Stabilizer: 0.5% BSA; Preservative: 0.02% Sodium Azide
• Concentration: lot specific
• Purification: Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.; Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Shipping: Blue Ice
• Gene Name: aldehyde dehydrogenase 5 family member A1
• Database Link:
  P51649
• Background: Defects in ALDH5A1 are the cause of succinate semialdehyde dehydrogenase deficiency (SSADH deficiency) [MIM:271980]. SSADH deficiency is a rare inborn error in the metabolism of 4-aminobutyric acid (GABA) which leads to accumulation of 4-hydroxybutyric acid in physiologic fluids of patients. The disease is characterized by severe ataxia and by mildly retarded psychomotor development.
• Synonyms: SSADH; SSDH
• Note: Calculated Molecular Weight: 58.7kDa (NP_733936.1).

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Alanine, aspartate and glutamate metabolism, Butanoate metabolism, Metabolic pathways