TrkA (NTRK1) Rabbit Polyclonal Antibody

SKU AP18228PU-N

TrkA (NTRK1) rabbit polyclonal antibody

Product Data

• Application: WB
• Recommended Dilution: ELISA: 1/1,000.; Western blotting: 1/100 - 1/500.
• Reactivity: Human
• Antibody Host: Rabbit
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide selected from the Y791 region of human TrkA
• Specificity: This antibody reacts to TrkA pTyr791.
• Buffer: PBS with 0.09% (W/V) sodium azide; State: Liquid purified Ig
• Concentration: lot specific
• Purification: Affinity chromatography on Protein A
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.; Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Shipping: Blue Ice
• Gene Name: neurotrophic receptor tyrosine kinase 1
• Database Link:
  P04629
• Background: TRKA (also known as NTRK1)is a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in the TRKA gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer.
• Synonyms: NTRK1, TRK, Trk-A

Reference Data

• Protein Families: Druggable Genome, Protein Kinase, Transmembrane
• Protein Pathways: Apoptosis, Endocytosis, MAPK signaling pathway, Neurotrophin signaling pathway, Pathways in cancer, Thyroid cancer