ERp57 (PDIA3) (Center) Rabbit Polyclonal Antibody
| Product Data | |
| Application | WB |
|---|---|
| Recommended Dilution | ELISA: 1/1,000. Western blotting: 1/50 - 1/100. |
| Reactivity | Human |
| Antibody Host | Rabbit |
| Clonality | Polyclonal |
| Immunogen | KLH conjugated synthetic peptide selected from the Center region of human PDIA3 |
| Specificity | This antibody reacts to PDIA3. |
| Buffer | PBS with 0.09% (W/V) sodium State: Purified State: Liquid purified Ig |
| Concentration | lot specific |
| Purification | Prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS |
| Conjugation | Unconjugated |
| Storage | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
| Stability | Shelf life: one year from despatch. |
| Shipping | Blue Ice |
| Gene Name | protein disulfide isomerase family A member 3 |
| Database Link | |
| Background | PDIA3 is the endoplasmic reticulum that interacts with lectin chaperones calreticulin and calnexin to modulate folding of newly synthesized glycoproteins. The protein was once thought to be a phospholipase; however, it has been demonstrated that the protein actually has protein disulfide isomerase activity. It is thought that complexes of lectins and this protein mediate protein folding by promoting formation of disulfide bonds in their glycoprotein substrates. |
| Synonyms | Protein disulfide-isomerase A3, ERP57, ERP60, GRP58, Protein Disulfide Isomerase, ER marker |
| Reference Data | |
| Protein Families | Druggable Genome |
| Protein Pathways | Antigen processing and presentation |
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