MyoGEF (PLEKHG6) (N-term) Rabbit Polyclonal Antibody

SKU AP17576PU-N

MyoGEF (PLEKHG6) (N-term) rabbit polyclonal antibody

Product Data

• Application: WB
• Recommended Dilution: ELISA: 1/1,000.; Western blotting: 1/100 - 1/500.
• Reactivity: Human
• Antibody Host: Rabbit
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide selected from the N-terminal region of human MyoGEF
• Specificity: This antibody reacts to MyoGEF.
• Buffer: PBS with 0.09% (W/V) sodium azide; State: Liquid purified Ig
• Concentration: lot specific
• Purification: Affinity chromatography on Protein A
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.; Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Shipping: Blue Ice
• Gene Name: pleckstrin homology and RhoGEF domain containing G6
• Database Link:
  Q3KR16
• Background: Guanine nucleotide exchange factor activating the small GTPase RHOA, which, in turn, induces myosin filament formation. It Also activates RHOG and does not activate RAC1, or to a much lower extent than RHOA and RHOG. Its part of a functional unit, involving PLEKHG6, MYH10 and RHOA, at the cleavage furrow to advance furrow ingression during cytokinesis. In epithelial cells, It is required for the formation of microvilli and membrane ruffles on the apical pole. Along with EZR, it is required for normal macropinocytosis.
• Synonyms: PLEKHG6

Reference Data