IRE1 (ERN2) (N-term) Rabbit Polyclonal Antibody

CAT#: AP13752PU-N

IRE1 (ERN2) (N-term) rabbit polyclonal antibody, Purified

Product Images

Western blot analysis of ERN2 (arrow) in mouse stomach tissue lysates (35ug/lane) using ERN2 / IRE2 antibody. (N-term).

Specifications

Product Data

• Applications: WB
• Recommended Dilution:

  Western blot: 1/1000.
  Enzyme immunoassay: 1/1000.

• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human ERN2.
• Specificity: This antibody reacts to ERN2 / IRE2.
• Formulation: PBS with 0.09% (W/V) sodium azide
  State: Purified
  State: Liquid purified Ig
• Concentration: lot specific
• Purification: Prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: endoplasmic reticulum to nucleus signaling 2
• Database Link:
  Entrez Gene 10595 Human
  UniProt ID Q76MJ5
• Background: ERN2 induces translational repression through 28S ribosomal RNA cleavage in response to endoplasmic reticulum (ER) stress. This pro-apoptotic appears to play no role in the unfolded-protein response, unlike closely related proteins. Overexpression of ERN2 activates both BiP and CHOP expression, and also leads to the development of programmed cell death. It has been suggested that Ern2 plays a role in multiple facets of the ER stress response in mammalian cells.
• Synonyms: Inositol-requiring protein 2, Ire1-beta