FANCF Rabbit Polyclonal Antibody

SKU AP09249PU-N

FANCF rabbit polyclonal antibody, Aff - Purified

Product Data

• Application: ELISA, WB
• Recommended Dilution: ELISA: 1:15,000 - 1:60,000.; Western blot: 1:1,000 - 1:5,000 (Expect a band approximately 42 kDa in size corresponding to FANCF in the appropriate human tissue).
• Reactivity: Chimpanzee, Human
• Antibody Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to an internal amino acid sequence of human FANCF
• Specificity: This affinity purified antibody is directed against FANCF protein.
• Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2, 0.01% (w/v) Sodium Azide; State: Aff - Purified; State: Liquid sterile filtered Ig fraction
• Concentration: lot specific
• Purification: Immunoaffinity chromatography
• Conjugation: Unconjugated
• Storage: Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing. Should this product contain a precipitate we recommend microcentrifugation before use.
• Stability: Shelf life: one year from despatch.
• Shipping: Blue Ice
• Gene Name: Fanconi anemia complementation group F
• Database Link:
  Q9NPI8
• Background: FANCF (also called Protein FACF or Fanconi Anemia Group F protein) is involved in DNA repair, perhaps specifically with post-replication repair or a cell cycle checkpoint function. FANCF has also been implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. FANCF belongs to the multi-subunit Fanconi Anemia (FA) complex composed of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9 and FANCM. The complex is not found in FA patients. FANCF is found within the nucleus. Defects in FANCF are a cause of Fanconi anemia (FA). FA is a genetically heterogeneous, autosomal recessive disorder characterized by progressive pancytopaenia, a diverse assortment of congenital malformations, and a predisposition to the development of malignancies. At the cellular level, it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage), and defective DNA repair.
• Synonyms: Fanconi anemia group F protein, FACF

Reference Data