IL7R alpha (IL7R) pTyr449 Rabbit Polyclonal Antibody

SKU AP09011PU-N

IL7R alpha (IL7R) pTyr449 rabbit polyclonal antibody, Aff - Purified

Product Data

• Application: ELISA, IHC, WB
• Recommended Dilution: ELISA: 1/100000.; Immunohistochemistry on Paraffin Sections: 5 µg/ml.; Western Blot: 1/1000 - 1/10000.
• Reactivity: Human, Mouse, Rat
• Antibody Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to residues near Tyr449 of Mouse IL-7 protein
• Specificity: This antibody recognizes Interleukin 7 Receptor Alpha Chain (IL7R). ; This phospho-specific polyclonal antibody reacts with Mouse IL-7 pY449 and shows minimal reactivity by ELISA against the non-phosphorylated form of the immunizing peptide.
• Buffer: 0.02M Potassium Phosphate, pH 7.2 with 0.15 M Sodium Chloride; State: Aff - Purified; State: Liquid purified Ig fraction; Preservative: 0.01% Sodium Azide
• Concentration: lot specific
• Purification: Immunoaffinity Chromatography
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.; Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Shipping: Blue Ice
• Gene Name: interleukin 7 receptor
• Database Link:
  P16871
• Background: Interleukin 7 Receptor (IL7R) is a receptor for interleukin 7 (IL7). The function of IL7R requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukine 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in the V(D)J recombination during lymphocyte development. This protein is also found to control the accessibility of the TCR gamma locus by STAT5 and histone acetylation. Knockout studies in mice suggested that blocking apoptosis is an essential function of this protein during differentiation and activation of T lymphocytes. The functional defects in this protein may be associated with the pathogenesis of the severe combined immunodeficiency (SCID).
• Synonyms: Interleukin-7 receptor subunit alpha, IL-7R-alpha, IL7 receptor alpha

Reference Data