SPARC Rabbit Polyclonal Antibody

SKU AP05261PU-N

SPARC rabbit polyclonal antibody, Aff - Purified

Product Data

• Application: ELISA, IHC, WB
• Recommended Dilution: ELISA.; Western Blot: 0.5-1 µg/ml.; Positive Control: Mouse heart lysate.; Immunohistochemistry.
• Reactivity: Human, Mouse
• Antibody Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic peptide derived from the Human SPARC protein
• Specificity: This antibody detects Human SPARC.; May cross react with SPARCL1.
• Buffer: Phosphate buffered saline with 0.08% Sodium Azide as preservative; State: Aff - Purified; State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Antigen Immunoaffinity Chromatography
• Conjugation: Unconjugated
• Storage: Upon arrival freeze at -20°C to -70°C.; Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Shipping: Blue Ice
• Gene Name: secreted protein acidic and cysteine rich
• Database Link:
  P09486
• Background: SPARC is a key factor in cell-matrix interactions and possibly tumour aggressiveness. The SPARC gene, which encodes a multifunctional glycoprotein with roles in tissue development, remodelling and fibrosis. A regulator of cell-extracellular matrix (ECM) interactions, SPARC represents a major factor in the ECM remodelling occurring during tumour invasion. in silico analysis reveals 4 UTR-SNPs located in the 3' UTR of the SPARC gene, corresponding to 1474 g a, 1551 g c, 1922 t g and 2072 c t changes, which are significantly associated with tumoral state of the tissue. Of all hits, the 2072 SPARC polymorphism had the best association with cancer.; SPARC therefore is a gene involved in a number of diseases including rheumatoid arthritis, scleroderma, tumor development and metastasis. SPARC variants have been detected in tumour samples of patients with acute myeloblastic leukemia (AML).
• Synonyms: ON, Basement-membrane protein 40, BM-40

Reference Data

• Protein Families: Druggable Genome