SH3BP2 Sheep Polyclonal Antibody

SKU AP05082PU-N

SH3BP2 sheep polyclonal antibody, Purified

Product Data

• Application: WB
• Recommended Dilution: Western Blot: Detects a 85 kDa band in murine fibroblasts transfected with 3BP2.
• Reactivity: Mouse
• Antibody Host: Sheep
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Antibody developed using SH2 domain of the 3BP2 protein fused to GST.
• Specificity: This antibody reacts to 3BP2.
• Buffer: Phosphate buffered saline and 0.08% sodium azide; State: Purified; State: Liquid purified Ig
• Concentration: lot specific
• Conjugation: Unconjugated
• Storage: The antibody can be shipped at ambient temperature. Store (in aliquots) at -20°C only.; Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Shipping: Blue Ice
• Gene Name: SH3 domain binding protein 2
• Database Link:
  P78314
• Background: 3BP2 (SH3 binding protein 2) was identified as a protein binding to the SH3 domain of the Abl proto-oncogene. Murine 3BP2 cDNA encodes a 559 amino acid protein of 85 kDa consisting of an N-terminal PH domain, a C-terminal SH2 domain and intervening proline-rich sequences. 3BP2 interacts via its Sh2 domain with Syk family protein tyrosine kinases Syk, Zap70, Grb2, Cbl, PLCg 1 and LAT in T lymphocytes and contributes to the transcriptional activation of NF-AT and AP-1. Mouse 3BP2 is 66% homologous to the human protein at the amino acid level.
• Synonyms: SH3 domain-binding protein 2, SH3BP-2, 3BP2, 3BP-2

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Natural killer cell mediated cytotoxicity