MAPT / TAU pSer262 Rabbit Polyclonal Antibody

SKU
AP02403PU-N
MAPT / TAU pSer262 rabbit polyclonal antibody, Aff - Purified
$430.00
2 Weeks*
Specifications
Product Data
Application IF, IHC, WB
Recommended Dilution Western Blot: 1/500-1/1000.
Immunofluorescence: 1/100-1/200.
Immunohistochemistry on Paraffin Sections: 1/50-1/100.
Reactivity Human, Mouse, Rat
Antibody Host Rabbit
Clonality Polyclonal
Immunogen Peptide sequence around phosphorylation site of serine 262 (I-G-S(p)-T-E) derived from Human Tau.
Specificity AP02403PU-N Antibody detects endogenous levels of Tau only when phosphorylated at Serine 262.
Buffer PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02% Sodium Azide and 50% Glycerol
State: Aff - Purified
State: Liquid purified Ig fraction
Concentration lot specific
Purification Affinity Chromatography using epitope-specific phosphopeptide.
Non-phosphospecific antibodies were removed by chromatogramphy using non-phosphopeptide.
Conjugation Unconjugated
Storage Upon receipt, store undiluted (in aliquots) at -20°C.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Shipping Blue Ice
Predicted Protein Size 48, 62, 78 kd.
Gene Name microtubule associated protein tau
Database Link
Background Tau is a neuronal microtubule associated protein found predominantly on axons. The function of Tau is to promote tubulin polymerisation and stabilise microtubules, but it also serves to link certain signalling pathways to the cytoskeleton. Tau, in its hyperphosphorylated form, is the major component of paired helical filaments (PHF) and neurofibrillary lesions in Alzheimer's disease (AD) brain. Hyperphosphorylation impairs the microtubule binding function of Tau, resulting in the destabilisation of microtubules in AD brains, ultimately leading to the degeneration of the affected neurons. Hyperphosphorylated tau is also found in a range of other central nervous system disorders. Numerous serine/threonine kinases, including GSK3 beta, PKA, Cdk5, and casein kinase II can phosphorylate Tau.
Synonyms MAPTL, MTBT1, Microtubule-associated protein tau, PHF-tau, Neurofibrillary tangle protein, Paired helical filament-tau
Reference Data
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.