Angiotensin II Type 1 Receptor (AGTR1) Rabbit Polyclonal Antibody
| Product Data | |
| Application | ELISA, IF, WB |
|---|---|
| Recommended Dilution | Western blot: 1/500-1/1000. Immunofluorescence: 1/50-1/200. |
| Reactivity | Human, Mouse, Rat |
| Antibody Host | Rabbit |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide, corresponding to amino acids 110-160 of Human AT1. |
| Specificity | This antibody detects endogenous levels of Type-1 angiotensin II receptor (AT1) (region surrounding Leu143). |
| Buffer | Phosphate buffered saline (PBS) State: Aff - Purified State: Liquid purified Ig fraction Preservative: 15mM Sodium azide |
| Concentration | 1.0 mg/ml |
| Purification | Affinity-chromatography using epitope-specific immunogen |
| Conjugation | Unconjugated |
| Storage | Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
| Stability | Shelf life: one year from despatch. |
| Shipping | Blue Ice |
| Predicted Protein Size | ~ 40 kDa |
| Gene Name | angiotensin II receptor type 1 |
| Database Link | |
| Background | AT1 receptor for angiotensin II; Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system and mediates the major cardiovascular effects of angiotensin II. It may play role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. |
| Synonyms | AT1AR, AT1BR, AGTR1, AGTR1A, AGTR1B, AT2R1, AT2R1B |
| Reference Data | |
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